Devyser PCR kits

The Devyser CVD kit can be used to identify seven genetic risk factors associated with the development of cardiovascular disease. The kit recognises the following risk factors:

• Factor XIII (F13A1) V34L variant
• Fibrinogen Beta Chain (FGB) gene’s 455G>A polymorphism
• Human Platelet Antigen 1 (HPA1b)/Platelet receptor GPIIIa/(ITGB3)
• Angiotensin Converting Enzyme (ACE) 287bp deletion/insertion polymorphism
• Angiotensin/Angiotensinogen (AGT) M268T polymorphism
• Angiotensin II type 1 receptor (AGTR1) 1166A>C (c.*86a>C) polymorphism
• Cystathionine Beta-Synthase (CBS) 844ins68 variant

Single-tube PCR reduces the possibility of errors and speeds up analysis.

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Devyser’s product portfolio includes two kits for infertility diagnostics: AZF and AZF extension for the study of microdeletions in the Y chromosome.

Y-chromosomal microdeletions are the most common genetic cause of unexplained sperm disorders and infertility in men. In men with azoospermia (no sperm count) or severe oligospermia (low sperm concentration or low sperm count), a study of Y chromosomes has shown that the chromosome (Yq11) consists of three regions, AZFa, AZFb and AZFc, where microdeletions are frequent. The screening of these microdeletions is a routine procedure in several infertility clinics.

Devyser AZF and AZF extension

Devyser AZF is CE-IVD marked kit used to study microdeletions in the AZFa, AZFb and AZFc regions of the Y chromosome by QF-PCR replication and capillary electrophoresis separation. The kit covers all STS markers and control sequences recommended by the EAA (European Academy of Andrology) and the EMQN (European Quality Monitoring Network Group) for the study of microdeletions in the Y chromosome.

The Devyser AZF Extension kit is available for further analysis of the identified deletion according to the recommendations. Ethidium bromide, which is traditionally used in AZF diagnostics, is not used in the test.

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Devyser’s prenatal tests are used to analyse the most common foetal abnormalities in a streamlined and precise fashion. All tests are based on reliable quantitative multiplex PCR replication and capillary electrophoresis-based fragment size separation.

PCR tests are faster and more cost-effective than conventional cytogenetic FISH or karyotype tests, the results of which may also be affected by failed cultures, poor quality chromosome preparations or maternal cell contamination, for example. In laboratories that have switched to non-invasive prenatal diagnostics (NIPT), Devyser’s tests act as a reliable confirmatory test for positive or failed analyses.

Devyser’s range of prenatal tests includes kits of varying sizes for varying needs. Tests do not require time-consuming cell culture, but are performed from a small amount of sample material, and the results are available within the same working day. The kits are CE IVD marked and used routinely in more than 50 countries.

Devyser Compact IVDR – single reaction mixture QF-PCR

• Covers 26 genetic markers in chromosomes 13, 18, 21 and XY
• Duration of the manual phases less than 45 minutes
• For the diagnosis of Down, Edwards, Patau and Klinefelter syndromes
• Two dedicated markers for X chromosome counts and detection of Turner syndrome
• IVDR certified

Devyser Complete – wider QF-PCR of two reaction mixtures

• Covers 33 genetic markers in chromosomes 13, 18, 21 and XY
• Duration of the manual phases less than 90 minutes
• For the diagnosis of Down, Edwards, Patau and Klinefelter syndromes
• Two dedicated markers for X chromosome counts and detection of Turner syndrome

Devyser Extend – the largest aneuploidy test

• Covers 42 genetic markers in chromosomes 13, 15, 16, 18, 21, 22 and XY
• Suitable for both prenatal diagnostics and miscarriage diagnostics
• Two dedicated markers for X chromosome counts and detection of Turner syndrome
• Available in two versions: v2 for all chromosome markers or M1 for chromosome 15, 16 and 22 markers only

Devyser Resolution – chromosome-specific diagnostics

• Devyser’s product range includes resolution kits for more accurate chromosome-specific diagnostics of chromosomes 13, 18 and 21 and sex chromosomes.

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Devyser RHD is a CE-IVD test kit used by clinical labs to determine fetal RHD status from maternal plasma as early as gestation week 10. Devyser’s unique single-exon design significantly simplifies your laboratory workflow and analysis. It also enables you to increase throughput and shorten turnaround times.

• User-friendly assay with high sensitivity and specificity
• Fast implementation
• CE-IVD

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